Joint health has come up as one of the most prevalent health issues in the world. As we age, the body’s ability to renew and maintain the supportive cartilage decreases. There may be less bio-synthesis of proteoglycans, leading to joint cartilage damage . On top of it, if the body is over weight, it increases the stress on joints. This results in joint stiffness, immobility and severe pain.

ORTHOTONE is the most effective treatment of Joint Pains/Osteoarthritis as it constitutes recommended CMDT dose of Chondroitin and Glucosamin sulfate , which has most effective results globally . It stimulates the production of glucosaminoglycans leading to increased synthesis of cartilage. It protects cartilage damage and repairs it efficiently in patients of joins. It relieves joint pains and improves mobility of patients.

Osteoarthritis is also known as WEAR AND TEAR ARTHRITIS. It is a degenerative joint disease which involves the deterioration of the cartilage protecting the ends of the bones. Once smooth surface of cartilage within the joints become rough, resulting in friction , which caused pain to the patient. Te normal smoothly sliding surface of bones become irregular. The tendons,ligaments and muscles holding the joint together become weaker and joint becomes deformed ,painful and stiff.

People go for extreme measures , such as surgery, steroids and other medical therapies with potential side effects.

The role of main ingredients of ORTHOTONE , has been recognized worldwide especially in the last few decades.

Millions of men and women suffering from joint problems are benefiting everyday from the best quality TVC supplement ingredients. Within two to three weeks of proper medications (one tablets , three times daily) of ORTHOTONE , they can eliminate the chances of undergoing painful expensive medical therapies and surgeries.

This multi action formula ,ORTHOTONE, features clinically studied components that have been found to provide joint comfort, support mobility, rebuild cartilage and lubricate joints.

The formulation of ORTHOTONE has been proven in over 300 studies and 20 clinical trials to actually build joint cartilage. This combination is necessary for development of connective tissues. Helps tremendously to relieve pain, inflammation and improves flexibility of joints. MSM acts as a natural pain killer and provides relief.

COMMENTS OF AMERICAN DOCTOR

What American Doctors say :

Joseph C. Maroon, MD says:

As a practicing physician, I see patients everyday who have pain with every step they take. Often physicians then get out their prescription pad and start writing for pain pills, which can cause sleepiness and addiction, or non-steroidal anti-inflammatories of which some have been linked to serious heart and blood vessel problems. An excellent natural alternative is glucosamine and chondroitin sulfate ( ACTIVE INGREDIENTS OF ORTHOTONE) , which are substances found naturally in the body. Glucosamine sulfate is a form of amino sugar that is believed to play a role in cartilage formation and repair. Chondroitin sulfate is part of a large protein molecule (proteoglycan) that gives cartilage elasticity. Both glucosamine and chondroitin sulfate are dietary or nutritional supplements. They are extracted from animal tissue: glucosamine from crab, lobster or shrimp shells; and chondroitin sulfate from animal cartilage. Patients with these pains should take these supplements regularly and it is very beneficial for their treatment.

What do they do?

The National Institutes of Health has recently concluded the GAIT trial designed to assess glucosamine and chondroitin sulfate used for reducing pain and improving function for patients with knee osteoarthritis shows positive results. Specifically, the GAIT results on over 1,500 patients show significant improvement of pain in those patients with moderate to severe arthritic knee pain. 
“ ……… participants with moderate-to-severe pain, glucosamine combined with chondroitin sulfate provided statistically significant pain relief compared to placebo--about 79 percent had a 20 percent or greater reduction in pain versus about 54 percent for placebo.”

Source: http://nccam.nih.gov/research/results/gait/qa.htm

RESEARCHES  ON GLUCOSAMINE SULFATE , MAJOR INGREDIENT OF ORTHOTONE:

1. In the past many studies suggested that this cartilage derivative could provide means for cartilage repair but doubts existed whether it had the ability to absorb glucosamine. Now recent studies have demonstrated that glucosamine (ORTHOTONE ingredient) can be absorbed and distributed to the joints as well as demonstrating anti-inflammatory and anabolic properties.
2. A landmark study, released in January 2001, suggested that oral glucosamine (ORTHOTONE ingredient) supplements  not only offer significant symptom relief, but also retards the progression of symptomatic knee osteoarthritis. This is the first significant breakthrough in the treatment of Osteoarthritis. Up until now, the goal of the therapy was to control the symptoms. There were/are no drugs that have been shown to favorably modify the disease process and interfere with disease progression. This new study offers hope for millions of Americans and patients across the globe.

RESEARCHES  ON CHONDROITIN SULFATE , MAJOR INGREDIENT OF ORTHOTONE:

1.Two recent meta-analyses indicate that chondroitin sulfate(ORTHOTONE ingredient) is useful in the treatment of osteoarthritis. One of these meta-analyses included all double-blind, placebo-controlled trials that lasted four weeks or longer. This meta-analysis also included trials that studied the effects of glucosamine (see Glucosamine) on osteoarthritis. In all, there were 13 of these studies (six involving glucosamine and seven involving chondroitin sulfate).
2.All  studies found positive results in hip or knee osteoarthritis. The authors of the meta-analysis judged a trial positive if there was 25% or more improvement in the treatment group compared with placebo. The Levesque Index and global pain scores were used to assess improvement. Very significant improvement was associated with both glucosamine (39.5%) and chondroitin (40.2%), compared with placebo.
3. In another recent meta-analysis of chondroitin sulfate, this one examining four randomized double-blind, placebo- or NSAID-controlled studies of 227 patients, chondroitin sulfate(ORTHOTONE ingredient) supplemented subjects showed at least 50% improvement, compared with controls. Various studies have reported significant reduction in NSAID use among osteoarthritis subjects supplemented with chondroitin sulfate.
4. There is also radiological evidence of chondroitin's (ORTHOTONE ingredient) possible efficacy in osteoarthritis. Knee joint space decreased significantly in placebo subjects but remained unchanged in those receiving chondroitin sulfate for a year. And, in another study, those receiving chondroitin sulfate showed significantly fewer instances of erosive osteoarthritis (compared with placebo controls) on hand radiographs over a three-year period.
5. A significant synergistic effect has been reported recently using combined glucosamine hydrochloride and chondroitin sulfate in an experimental study. The combination was more effective than either substance alone in inhibiting progression of degenerative cartilage lesions
6. It is believed that chondroitin sulfate's possible efficacy in osteoarthritis derives from the fact that it is one of the two most abundant glycosaminoglycans (GAGs) in articular cartilage. Supplementation with this GAG seems, in part at least, to confer chondroprotection through its inhibitory action on some of the enzymes that damage cartilage. Further, by inhibiting other enzymes that can block transport of nutrients that nourish cartilage, this GAG may promote cartilage replacement.
7. It has been known for some time that injections of hyaluronic acid into arthritic joints can bring significant pain relief and enhanced mobility. Thus it is logical to assume that chondroitin sulfate, if it can reach the joints, may have similar effects since this substance has the ability to bind to receptor sites on synovial cell surfaces and thus induce production of hyaluronic acid, crucial to joint mobility.
The question for some time was whether a large molecule like chondroitin sulfate could achieve this penetration. Recent studies demonstrate that a low-molecular-weight version of oral chondroitin sulfate, of the sort used in all of the U.S. clinical trials, is absorbed.
8. Some years ago, chondroitin sulfate was investigated for its possible use in atherosclerosis. There was some evidence that it could favorably lower lipid levels and protect against blood clotting. Atheromatous aortic lesions were prevented in animals on high-cholesterol diets.
9. In a clinical trial, 60 patients suffering from coronary artery disease received 2 grams of oral chondroitin sulfate daily for 900 days. During that period, 16 of 60 unsupplemented control patients suffered acute coronary incidents. Only one of the chondroitin sulfate-treated subjects had an acute coronary incident. The same research group later followed up with similarly positive results.

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